Placental Bed Disorders: Basic Science and its Translation to Obstetrics
It is now recognized that defective placentation in the human is a cause of many pregnancy complications, such as spontaneous abortion, preterm labor and delivery, pre-eclampsia, intrauterine growth restriction, fetal death and abruptio placenta. These clinical disorders can often have long-term consequences into adulthood, causing cardiovascular disease, obesity and diabetes for the newborn as well as an increased risk of premature death in the mother. This is the first book to be entirely focused on the placental bed, bringing together the results of basic and clinical research in cell biology, immunology, endocrinology, pathology, genetics and imaging to consolidate in a single, informative source for investigators and clinicians. Its core aim is to explore new approaches and improve current clinical practice. This is essential reading for clinicians in obstetric, cardiovascular and reproductive medicine.
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The search for susceptibility genes 174 Section 8 Translation
decidua trophoblast or and research models 109
Immune cells in the placental bed
Department of Medicine Obstetrics and Gynecology Women and Childrens Hospital
Boston MA USA Robert D Martin
Placental angiogenesis 52 Robert H Lane Robert A McKnight and Qi
Oxygen delivery at the deciduoplacental Section 6 Genetics
Division of Molecular and Vascular Medicine Salt Lake City
Carter David Haig
Angiogenic factors and preeclampsia
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aﬀects altricial angiogenesis angiogenic apoptosis associated Biol birth weight Brosens chorionic Clin cycles cytotrophoblasts diﬀerent diﬀerentiation early pregnancy eclampsia eﬀect embryo transfer endometrial and subendometrial endometrium endothelial cells endotheliochorial endovascular trophoblast epitheliochorial extravillous trophoblast Fertil Steril fetus ﬁndings ﬁrst trimester function genetic gestation growth factor growth restriction hemochorial HLA-C HLA-G Hum Reprod human placenta human pregnancy hypertension Immunol implantation increased inﬂuence interactions interstitial trophoblast intervillous space IUGR Jauniaux junctional zone Laurasiatheria maternal blood membranes mice molecules myometrial myometrium natural killer cells neonates normal Obstet Gynecol oﬀspring oxidative oxygen phenotype physiological Pijnenborg placental bed placental mammals PlGF power Doppler preeclampsia preterm primates progesterone protein receptor risk role signiﬁcant signiﬁcantly species speciﬁc spiral arteries strepsirrhines stromal cells studies subendometrial blood ﬂow syncytiotrophoblast tion tissue tropho trophoblast cells trophoblast invasion uIUGR ultrasound uNK cells uteroplacental uterus vascular remodeling VEGF vessels villi villous vitro women