Placental Bed Disorders: Basic Science and its Translation to ObstetricsRobert Pijnenborg, Ivo Brosens, Roberto Romero Cambridge University Press, 3. juuni 2010 It is now recognized that defective placentation in the human is a cause of many pregnancy complications, such as spontaneous abortion, preterm labor and delivery, pre-eclampsia, intrauterine growth restriction, fetal death and abruptio placenta. These clinical disorders can often have long-term consequences into adulthood, causing cardiovascular disease, obesity and diabetes for the newborn as well as an increased risk of premature death in the mother. This is the first book to be entirely focused on the placental bed, bringing together the results of basic and clinical research in cell biology, immunology, endocrinology, pathology, genetics and imaging to consolidate in a single, informative source for investigators and clinicians. Its core aim is to explore new approaches and improve current clinical practice. This is essential reading for clinicians in obstetric, cardiovascular and reproductive medicine. |
Contents
5 | |
11 | |
22 | |
29 | |
Immune cells in the placental bed | 41 |
Placental angiogenesis | 52 |
Oxygen delivery at the deciduoplacental | 63 |
Endometrial and subendometrial blood flow | 85 |
Section 6 | 160 |
The search for susceptibility genes | 174 |
Imprinting | 183 |
Risk factors predictors | 195 |
Assisted reproductive technology and the risk | 207 |
Division of Molecular and Vascular Medicine Salt Lake City | 215 |
Angiogenic factors and preeclampsia | 229 |
Bergen Norway Guy St J Whitley Division of Basic Medical Sciences | 243 |
Deep trophoblast invasion and spiral artery | 97 |
Comparative anatomy | 109 |
Animal models of deep trophoblast | 127 |
Trophoblastarterial interactions in vitro | 140 |
Longterm effects of uteroplacental | 149 |
New concepts and recommendations | 256 |
Placental bed disorders in the genesis of | 271 |
Index | 290 |
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Placental Bed Disorders: Basic Science and its Translation to Obstetrics Robert Pijnenborg,Ivo Brosens,Roberto Romero No preview available - 2010 |
Common terms and phrases
angiogenesis angiogenic apoptosis associated Biol birth weight Brosens chorionic Clin cycles cytotrophoblasts decidual disease early pregnancy eclampsia embryo transfer endometrial endometrial and subendometrial endometrium endothelial cells endotheliochorial endovascular trophoblast epitheliochorial extravillous trophoblast Fertil Steril fetal growth fetus function gene expression genetic genome gestational age growth factor growth restriction hemochorial HLA-G Hum Reprod human placenta human pregnancy hypertension Immunol implantation imprinted genes increased interactions intrauterine IUGR Jauniaux junctional zone Laurasiatheria maternal blood membranes mice myometrial myometrium natural killer cells neonates normal Obstet Gynecol outcome perinatal phenotype physiological Pijnenborg placental bed PlGF power Doppler preeclampsia preeclamptic pregnancy primates progesterone protein receptor regulation risk of preeclampsia role singleton spiral arteries strepsirrhines stromal cells studies subendometrial blood flow tion tissue trimester trophoblast cells trophoblast invasion uIUGR ultrasound uNK cells uterine artery uteroplacental uterus vascular remodeling VEGF vessels villi villous vitro weeks women