Journal of the Royal Microscopical Society

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Royal Microscopical Society., 1890
... containing its transactions and proceedings and a summary of current researches relating to zoology and botany (principally Invertebrata and Cryptogamia), microscopy, &c.

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Page 769 - As regards the effect of the remedy on the human patient, it was clear from the beginning of the research that in one very important...
Page 16 - The Journal, containing the Transactions and Proceedings of the Society, and a Summary of Current Researches relating to Zoology and Botany (principally Invertebrata and Cryptogamia), Microscopy, &c...
Page 768 - I mentioned a remedy which conferred on the animals experimented upon an immunity against inoculation with the tubercle bacillus, and which arrested tuberculous disease. Investigations have now been carried out on human patients, and these form the subject of the following observations. It was originally my intention to complete the research, and especially to gain sufficient experience regarding the application of the remedy in practice, and its production on a large scale before publishing anything...
Page 772 - Cough and expectoration were generally increased a little after the first injection, then grew less and less, and in the most favorable cases entirely disappeared. The expectoration also lost its purulent character and became mucous. As a rule, the number of bacilli decreased only when the expectoration began to present a mucous appearance. They then entirely disappeared, but were again observed occasionally until expectoration completely ceased. Simultaneously the night-sweats ceased, the patients...
Page 769 - After twelve hours all these symptoms abated, the temperature fell, and on the next day it was normal. A feeling of fatigue and pain in the limbs continued for a few days, and for exactly the same period of time the site of injection remained slightly painful and red.
Page 770 - This is accompanied by pain in the limbs, coughing, great fatigue, and often sickness and vomiting. In several cases a slight icteroid discoloration was observed, and occasionally an eruption like measles on the chest and neck. The attack usually begins four to five hours after the injection, and lasts from twelve to fifteen hours. Occasionally it begins later and then runs its course with less intensity.
Page 770 - Generally, however, several injections are required for the complete removal of the lupus-tissue ; but of this, more later on. I must mention as a point of special importance that the changes described are exactly confined to the parts of the skin affected with lupus. Even the smallest nodules and those most deeply hidden in the...
Page 769 - The symptoms arising from an injection of 0.25 cubic centimetre I have observed after an injection made in my own upper arm. They were briefly as follows: three to four hours after the injection there came on pain in the limbs, fatigue, inclination to cough, difficulty...
Page 768 - As bacterial growths soon develop in them they become turbid, and are then unfit for use. To prevent this, the diluted liquid must be sterilized by heat and preserved under a cotton-wool stopper, or, more conveniently, prepared with a one half per cent, solution of phenol.
Page 770 - ... the remedy to a most surprising degree, A few hours after an injection into the skin of the back — that is, in a spot far removed from the diseased...

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