Such being the facts with respect to the Pébrine, what are the indications as to the method of preventing it? It is obvious that this depends upon the way in which the Panhistophyton is generated. If it may be generated by Abiogenesis, or by Xenogenesis, within the silkworm or its moth, the extirpation of the disease must depend upon the prevention of the occurrence of the conditions under which this generation takes place. But if, on the other hand, the Panhistophyton is an independent organism, which is no more generated by the silkworm than the mistletoe is generated by the apple-tree or the oak on which it grows, though it may need the silkworm for its development in the same way as the mistletoe needs the tree, then the indications are totally different. The sole thing to be done is to get rid of and keep away the germs of the Panhistophyton. As might be imagined, from the course of his previous investigations, M. Pasteur was led to believe that the latter was the right theory; and, guided by that theory, he has devised a method of extirpating the disease, which has proved to be completely successful wherever it has been properly carried out.

There can be no reason, then, for doubting that, among insects, contagious and infectious diseases, of great malignity, are caused by minute organisms which are produced from pre-existing germs, or by homogenesis; and there is no reason, that I know of, for believing that what happens in insects may

not take place in the highest animals. Indeed, there is already strong evidence that some diseases of an extremely malignant and fatal character to which man is subject, are as much the work of minute organisms as is the Pébrine. I refer for this evidence to the very striking facts adduced by Professor Lister in his various well-known publications on the antiseptic method of treatment. It appears to me impossible to rise from the perusal of those publications without a strong conviction that the lamentable mortality which so frequently dogs the footsteps of the most skilful operator, and those deadly consequences of wounds. and injuries which seem to haunt the very walls of great hospitals, and are, even now, destroying more men than die of bullet or bayonet, are due to the importation of minute organisms into wounds, and their increase and multiplication; and that the surgeon who saves most lives will be he who best works out the practical consequences of the hypothesis of Redi.

I commenced this Address by asking you to follow me in an attempt to trace the path which has been followed by a scientific idea, in its long and slow progress from the position of a probable hypothesis to that of an established law of nature. Our survey has not taken us into very attractive regions; it has lain, chiefly, in a land flowing with the abominable, and peopled with mere grubs and mouldiness. And it may be imagined with what

smiles and shrugs, practical and serious contemporaries of Redi and of Spallanzani may have commented on the waste of their high abilities in toiling at the solution of problems which, though curious enough in themselves, could be of no conceivable utility to mankind.

Nevertheless, you will have observed that before we had travelled very far upon our road, there appeared, on the right hand and on the left, fields laden with a harvest of golden grain, immediately convertible into those things which the most solidly practical men will admit to have value-viz., money and life.

The direct loss to France caused by the Pébrine in seventeen years cannot be estimated at less than fifty millions sterling; and if we add to this what Redi's idea, in Pasteur's hands, has done for the wine-grower and for the vinegarmaker, and try to capitalise its value, we shall find that it will go a long way towards repairing the money losses caused by the frightful and calamitous war of this autumn. And as to the equivalent of Redi's thought in life, how can we over-estimate the value of that knowledge of the nature of epidemic and epizootic diseases, and consequently of the means of checking, or eradicating them, the dawn of which has assuredly commenced?

Looking back no further than ten years, it is possible to select three (1863, 1864, and 1869) in

which the total number of deaths from scarletfever alone amounted to ninety thousand. That is the return of killed, the maimed and disabled being left out of sight. Why, it is to be hoped that the list of killed in the present bloodiest of all wars will not amount to more than this! But the facts which I have placed before you must leave the least sanguine without a doubt that the nature and the causes of this scourge will, one day, be as well understood as those of the Pébrine are now; and that the longsuffered massacre of our innocents will cɔme to an end.

And thus mankind will have one more admonition that "the people perish for lack of knowledge"; and that the alleviation of the miseries, and the promotion of the welfare, of men must be sought, by those who will not lose their pains, in that diligent, patient, loving study of all the multitudinous aspects of Nature, the results of which constitute exact knowledge, or Science. It is the justification and the glory of this great meeting that it is gathered together for no other object than the advancement of the moiety of science which deals with those phenomena of nature which we call physical. May its endeavours be crowned with a full measure of success!

IX

GEOLOGICAL CONTEMPORANEITY AND PERSISTENT TYPES OF LIFE

[1862]

MERCHANTS Occasionally go through a wholesome, though troublesome and not always satisfactory, process which they term "taking stock." After all the excitement of speculation, the pleasure of gain, and the pain of loss, the trader makes up his mind to face facts and to learn the exact quantity and quality of his solid and reliable possessions.

The man of science does well sometimes to imitate this procedure; and, forgetting for the time the importance of his own small winnings, to re-examine the common stock in trade, so that he may make sure how far the stock of bullion in the cellar on the faith of whose existence so much paper has been circulating—is really the solid gold of truth.

The Anniversary Meeting of the Geological